ABSTRACT

Background

This study examined whether a particular type of childhood trauma (CT) is more prevalent in people diagnosed with bipolar disorder than in a matched sample of people diagnosed with schizophrenia and whether clinical variables of bipolar disorder are related to CT.

Methods

Seventy-one inpatients diagnosed with bipolar disorder were matched to those diagnosed with schizophrenia for age, sex, and duration of illness. Both groups completed the Childhood Trauma Questionnaire, the Traumatic Antecedent Questionnaire, the Impact of Events Scale, and the Dissociative Experiences Scale-Taxon. Second, clinical variables at discharge, course variables within one year (relapse, readmission, and time remained in therapy) and medication adherence were investigated for association with trauma types.

Results

Reported CT and protective factors did not differ between those diagnosed with bipolar disorder and schizophrenia. In addition, CT was not related to clinical features, course variables or medication adherence. The only significant correlations found were between childhood emotional neglect and prescription of anxiolytics (p < 0.05) and sleep pills (p < 0.001) at discharge.

Conclusions

We did not find any particular type of CT that distinguishes bipolar disorder from schizophrenia, implying there is no specific contribution of CT to different psychotic diagnoses. However, some types of trauma may correlate with the prescription of specific psychotropic medication.

中文翻译：

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诊断为躁郁症的住院患者中儿童期创伤的患病率和临床相关性：与精神分裂症的匹配比较

摘要

背景

这项研究调查了在诊断为躁郁症的人中是否比在诊断为精神分裂症的人群中更普遍的一种特殊类型的童年创伤（CT），以及躁郁症的临床变量是否与CT相关。

方法

在年龄，性别和病程方面，对被诊断为躁郁症的住院患者和诊断为精神分裂症的住院患者进行了匹配，共71例。两组均完成了《儿童创伤问卷》，《创伤前期问卷》，《事件影响量表》和《离体经历量表》。其次，研究了出院时的临床变量，一年内的疗程变量（复发，再入院和治疗中的剩余时间）以及药物依从性与创伤类型的关系。

结果

所报告的CT和保护因素在诊断为躁郁症和精神分裂症的患者中没有差异。此外，CT与临床特征，病程变量或药物依从性无关。发现的唯一显着相关性是儿童出院时的情感疏忽与抗焦虑药处方（p <0.05）和安眠药（p <0.001）之间。

结论

我们没有发现任何将双相情感障碍与精神分裂症区分开的特殊类型的CT，这意味着CT对不同的精神病学诊断没有特定的贡献。但是，某些类型的创伤可能与特定的精神药物处方有关。