Membranes or skin dressing are common treatments for skin wound injuries, collagen being one the most effective materials for their manufacturing. Many different sources of collagen with diverse methods of extraction and processing have been used, with evidence of positive effects on the stimulation of skin wound healing. In spite of these factors, there is still limited understanding of the interaction between collagen membranes and biological tissues, especially due to the series of different types of collagen origin. In this context, this study aimed to conduct a systematic review of the available literature examining the effect of various collagen membranes for accelerating skin wound healing in experimental animal models and clinical trials. The present review was performed from March to May of 2020 searching in two databases (PubMed and Scopus). The following Medical Subject Headings (MeSH) descriptors were used: “collagen”, “dressing”, “membranes”, “skin” and “wound”. After the eligibility assessment, 16 studies were included and analyzed. The studies demonstrated that collagen was obtained predominantly from bovine and porcine sources, by acetic acid and/or enzyme dissolution. Additionally, most of the studies demonstrated that the membranes were processed mainly by freeze-drying or lyophilization methods. All the in vivo and clinical trial studies evidenced positive outcomes in the wound healing process, thus confirming that collagen membranes are one of the most efficient treatment for skin wounds, highlighting the enormous potential of this biomaterial to be used for skin tissue engineering purposes.

膜或皮肤敷料是皮肤伤口损伤的常用治疗方法，胶原蛋白是制造它们的最有效材料之一。已经使用了许多不同来源的胶原蛋白以及不同的提取和加工方法，有证据表明它们对刺激皮肤伤口愈合有积极作用。尽管存在这些因素，但对胶原膜与生物组织之间相互作用的了解仍然有限，尤其是由于一系列不同类型的胶原来源。在此背景下，本研究旨在对现有文献进行系统评价，研究各种胶原膜在实验动物模型和临床试验中加速皮肤伤口愈合的作用。本综述于 2020 年 3 月至 5 月在两个数据库（PubMed 和 Scopus）中进行搜索。使用了以下医学主题词 (MeSH) 描述符：“胶原蛋白”、“敷料”、“膜”、“皮肤”和“伤口”。资格评估后，纳入并分析了 16 项研究。研究表明，胶原蛋白主要通过乙酸和/或酶溶解从牛和猪来源获得。此外，大多数研究表明，膜主要通过冷冻干燥或冻干方法进行处理。所有 研究表明，胶原蛋白主要通过乙酸和/或酶溶解从牛和猪来源获得。此外，大多数研究表明，膜主要通过冷冻干燥或冻干方法进行处理。所有 研究表明，胶原蛋白主要通过乙酸和/或酶溶解从牛和猪来源获得。此外，大多数研究表明，膜主要通过冷冻干燥或冻干方法进行处理。所有体内和临床试验研究证明了伤口愈合过程中的积极成果，从而证实胶原膜是皮肤伤口最有效的治疗方法之一，突出了这种生物材料用于皮肤组织工程目的的巨大潜力。