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Global Warming and Neurological Practice: Systematic Review
medRxiv - Neurology Pub Date : 2020-12-22 , DOI: 10.1101/2020.12.18.20248515
C Peinkhofer , M Amiri , MH Othman , T De Vecchi , V Nersesjan , D Kondziella

Background: Climate change, including global warming, is expected to cause poorer global health and a rise in the number of environmental refugees. As neurological disorders account for a major share of worldwide morbidity and mortality, climate change and global warming are also destined to alter neurological practice; however, to what extent and by which mechanisms is unknown. We aimed to collect the available information on the effects of ambient temperatures and human migration on the epidemiological and clinical manifestations of major neurological disorders. Methods: We searched PubMed and Scopus from January 1, 2000 to November 30, 2020 for human studies published in English addressing the influence of ambient temperatures and human migration on Alzheimer and non-Alzheimer dementia, epilepsy, headache and migraine, multiple sclerosis, Parkinson disease, stroke, and tick-borne encephalitis (as a model disease for neuroinfections). The protocol was pre-registered at PROSPERO (2020 CRD42020147543). Results: 101 studies met inclusion criteria, but we were unable to identify a single study addressing how global warming and human migration will change neurological practice. Still, extracted data suggested multiple ways by which these aspects might alter neurological morbidity and mortality in the future. Conclusion: Significant heterogeneity exists across studies with respect to methodology, outcome measures, control of confounders and study design, but there is enough evidence to suggest climate change will impact the neurological practice of all major neurological disorders. Adequately designed studies to address this issue are urgently needed, which will require concerted efforts from the entire neurological community.

中文翻译:

全球变暖和神经病学实践:系统评价

背景:气候变化,包括全球变暖,预计将导致全球健康状况恶化,环境难民人数增加。由于神经系统疾病在全球发病率和死亡率中占很大比重,因此气候变化和全球变暖也注定会改变神经系统实践。但是,在何种程度上以及通过何种机制未知。我们旨在收集有关环境温度和人类迁徙对主要神经系统疾病的流行病学和临床表现的影响的可用信息。方法:我们从2000年1月1日至2020年11月30日在PubMed和Scopus上搜索了英语研究的人类研究,研究环境温度和人类迁徙对阿尔茨海默氏症和非阿尔茨海默氏痴呆症,癫痫,头痛和偏头痛,多发性硬化症的影响,帕金森病,中风和and传性脑炎(作为神经感染的典型疾病)。该协议已在PROSPERO(2020 CRD42020147543)上预先注册。结果:101项研究符合纳入标准,但我们无法确定一项涉及全球变暖和人类迁徙将如何改变神经学实践的研究。尽管如此,提取的数据仍提出了这些方面将来可能改变神经系统发病率和死亡率的多种方式。结论:在研究方法,结果测量,混杂因素控制和研究设计方面,研究存在显着异质性,但有足够证据表明气候变化将影响所有主要神经系统疾病的神经系统实践。迫切需要针对此问题进行充分设计的研究,
更新日期:2020-12-22
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