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Photocross-linkable Methacrylated Polypeptides and Polysaccharides for Casting, Injecting, and 3D Fabrication
Biomacromolecules ( IF 6.2 ) Pub Date : 2020-12-22 , DOI: 10.1021/acs.biomac.0c01322
Hatai Jongprasitkul 1 , Sanna Turunen 1, 2 , Vijay Singh Parihar 1 , Shambhavee Annurakshita 3 , Minna Kellomäki 1
Affiliation  

For modern tissue engineering, we need not only develop new hydrogels but also suitable processing methods for them. Polypeptides and polysaccharides are potential candidates because they can be methacrylated, processed before photocross-linking, and yielded into hydrogels with given shape and form. In this study, we successfully methacrylated collagen, gelatin, hyaluronan, and alginate to 30 and 60% degree of modification. We studied methacrylated compositions (i.e., precursors) to investigate their processability. The precursors of collagen and gelatin with 60% methacrylation exhibited suitable yield stress, shear-thinning properties, and fiber-forming capability for injecting and 3D bioprinting. On the contrary, the 30% methacrylated precursors had properties suitable for casting purposes. Our study also showed that the mechanical properties of hydrogels corresponded to the used photocross-linking conditions and the degree of modification. These results underline the importance of tunability of the precursors and resulting hydrogels according to the specific fabrication method and tissue engineering application.

中文翻译:

可光交联的甲基丙烯酸甲酯化的多肽和多糖,用于铸造,注塑和3D加工

对于现代组织工程,我们不仅需要开发新的水凝胶,还需要为其开发合适的加工方法。多肽和多糖是潜在的候选物,因为它们可以被甲基丙烯酸酯化,在光交联之前进行加工,并产生给定形状和形式的水凝胶。在这项研究中,我们成功地将甲基丙烯酸胶原蛋白,明胶,透明质酸和藻酸盐甲基化至30%和60%的修饰度。我们研究了甲基丙烯酸酯化的组合物(即前体)以研究其可加工性。具有60%甲基丙烯酸酯化作用的胶原蛋白和明胶的前体表现出合适的屈服应力,剪切稀化特性以及用于注射和3D生物打印的成纤能力。相反,30%甲基丙烯酸酯化的前体具有适合于铸造目的的性能。我们的研究还表明,水凝胶的机械性能与所用的光交联条件和改性程度相对应。这些结果强调了根据特定的制造方法和组织工程应用,前体和所得水凝胶可调谐性的重要性。
更新日期:2021-02-08
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