Abstract

In this study, an ether-bridged aromatic carboxylic acid, 2-(2-carboxyphenoxy)terephthalic acid (H₃cpta), was applied as the building block for the generation of two new Co(II)-based coordination polymers (CPs) with the chemical formulae of [Co₃(μ₅-cpta)₂(2,2′-bipy)₂]_n (1, 2,2′-bipy = 2,2′-bipyridine) [Co₃(μ₃-cpta)₂(phen)₃(py)₃(H₂O)₃]_n (2, phen =1,10-phenanthroline, py = pyridine) by reaction of the Co(NO₃)₂·6H₂O with the H₃cpta ligand in the presence of different N-donor co-ligands under the hydrothermal reaction conditions. The single-crystal X-ray diffraction study shows that compound 1 features a 2D layered structure which has been reported previously and compound 2 shows a ladder-like 1D network. Furthermore, the treatment effect of compounds 1 and 2 on the rats undergoing gastrointestinal surgery was evaluated. The hemodynamics of the rats was measured after compound 1 or 2 treatment. Besides, the Richmond Agitation–Sedation Scale was also performed for the evaluation of rats' cognitive function after the treatment.

摘要

在这项研究中，醚桥连的芳族羧酸 2-(2-羧基苯氧基) 对苯二甲酸 (H ₃ cpta) 被用作生成两种新的 Co(II) 基配位聚合物 (CPs) 的基石化学式为 [Co ₃ (μ ₅ -cpta) ₂ (2,2'-bipy) ₂ ] _n ( 1 , 2,2'-bipy = 2,2'-bipyridine) [Co ₃ (μ ₃ - cpta) ₂ (phen) ₃ (py) ₃ (H ₂ O) ₃ ] _n ( 2 , phen =1,10-菲咯啉, py = 吡啶) 通过 Co(NO ₃) ₂ ·6H ₂ O 与H ₃ cpta 配体在不同的N-供体共配体存在下在水热反应条件下。单晶 X 射线衍射研究表明，化合物1具有之前报道过的二维层状结构，化合物2显示出梯状的一维网络。此外，还评估了化合物1和2对接受胃肠手术的大鼠的治疗效果。在化合物1或2之后测量大鼠的血流动力学治疗。此外，还进行了Richmond激越-镇静量表评估大鼠治疗后的认知功能。