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In vitro investigation of swelling triggered release of 5-fluorouracil from gelatin coated gold nanoparticles
Inorganic and Nano-Metal Chemistry ( IF 1.7 ) Pub Date : 2020-12-22 , DOI: 10.1080/24701556.2020.1862217
Nishi Verma 1 , Alka Tiwari 1 , Neha Sonker 2 , Jaya Bajpai 2 , Anil Kumar Bajpai 2
Affiliation  

Abstract

In the present study gelatin coated-gold nanoparticles were synthesized and release study of the drug “5-fluorouracil” (5-FU) was carried out in a controlled manner. Gelatin nanoparticles were prepared by single water in oil (W/O) emulsion crosslinking technique and gold (Au) nanoparticles by Turkvitch method. For preparing gelatin coated-Au nanoparticles, in situ method was adopted. The release kinetics of entrapped drug was investigated as a function of various experimental factors such as chemical composition of prepared nanoparticles, pH, temperature and simulated biological fluids as the release media. The 5-FU drug loaded nanoparticles were characterized by FTIR, SEM, TEM, XRD and in vitro cytotoxicity techniques. The drug release process was analyzed kinetically using Fickian power law, zero order, first order and Korsmeyer–Peppas models, respectively, and a correlation was established between the quantity of the released drug and swelling of the nanoparticles.



中文翻译:

溶胀引发 5-氟尿嘧啶从明胶包覆的金纳米粒子中释放的体外研究

摘要

在本研究中,合成了明胶涂层的金纳米颗粒,并以受控方式进行了药物“5-氟尿嘧啶”(5-FU)的释放研究。明胶纳米颗粒采用单油包水(W/O)乳液交联技术制备,金(Au)纳米颗粒采用Turkvitch法制备。采用原位法制备明胶包覆的金纳米粒子。包埋药物的释放动力学被研究为各种实验因素的函数,如制备的纳米颗粒的化学成分、pH 值、温度和作为释放介质的模拟生物流体。通过 FTIR、SEM、TEM、XRD 和体外对 5-FU 载药纳米颗粒进行表征细胞毒性技术。分别使用 Fickian 幂律、零阶、一阶和 Korsmeyer-Peppas 模型对药物释放过程进行动力学分析,并建立了释放药物量与纳米颗粒溶胀之间的相关性。

更新日期:2020-12-22
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