Abstract

Doxorubicin is an anticancer drug known for a variety of cancers. As a targeted drug, it is loaded onto branched graphene oxide nanoparticles (GONPs). In this research, polymeric coatings containing vinyl alcohol bonded of the fifth generation of dendrimers containing methyl methacrylate (MMA) and ethylenediamine (EDA) groups act as a responsive polymer.

The precursors are polymerized to form the dendrimer coating as the last carrier on the graphene oxide surface. Then polyvinyl alcohol (pH-sensitive polymer) coating is used on the surface of branched graphene oxide. When the nanoparticles carry the drug, they are not recognized by the immune system. The amount of drug release is increased. The average size of the final product is 30 nm. It is characterized by FTIR, TGA, XRD, and SEM-EDX to investigate different adsorption properties. Some of the physical parameters of the adsorption process, such as pH, time, and temperature for doxorubicin are investigated using the final adsorbent. The drug release by the adsorbent coated with pH-sensitive polymer is more than when the polymer coating was not applied on the nanoparticle. Drug release tests showed pH sensitivity behavior of graphene oxide/dendrimer/polyvinyl alcohol (GO/dendrimer/PVA), with %99.7 drug release at acidic (pH = 5.6) and %59 at neutral (pH = 7.4) conditions, that's means in the pH of a tumorous cell and the blood pH level, respectively.

摘要

阿霉素是一种因多种癌症而闻名的抗癌药物。作为靶向药物，将其加载到支链氧化石墨烯纳米颗粒（GONPs）上。在这项研究中，含有乙烯醇的聚合物涂料是由第五代包含甲基丙烯酸甲酯（MMA）和乙二胺（EDA）基团的树枝状聚合物键合而成的。

聚合前体以形成树枝状聚合物涂层，作为在氧化石墨烯表面上的最后载体。然后在支链氧化石墨烯的表面上使用聚乙烯醇（pH敏感聚合物）涂层。当纳米颗粒携带药物时，它们不会被免疫系统识别。药物释放量增加。最终产品的平均尺寸为30 nm。通过FTIR，TGA，XRD和SEM-EDX对其进行表征，以研究不同的吸附性能。使用最终吸附剂研究了吸附过程的一些物理参数，例如阿霉素的pH，时间和温度。与没有将聚合物涂层涂覆在纳米颗粒上时相比，被涂覆有pH敏感聚合物的吸附剂释放的药物更多。