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Sudden emergence of a Neisseria gonorrhoeae clade with reduced susceptibility to extended-spectrum cephalosporins, Norway
Microbial Genomics ( IF 3.9 ) Pub Date : 2020-12-01 , DOI: 10.1099/mgen.0.000480
Magnus N Osnes 1 , Xavier Didelot 2 , Jolinda de Korne-Elenbaas 3 , Kristian Alfsnes 1 , Ola B Brynildsrud 1 , Gaute Syversen 4 , Øivind Jul Nilsen 1 , Birgitte Freiesleben De Blasio 1, 5 , Dominique A Caugant 1, 6, 7 , Vegard Eldholm 1, 6
Affiliation  

Neisseria gonorrhoeae multilocus sequence type (ST)-7827 emerged in a dramatic fashion in Norway in the period 2016–2018. Here, we aim to shed light on the provenance and expansion of this ST. ST-7827 was found to be polyphyletic, but the majority of members belonged to a monophyletic clade we termed PopPUNK cluster 7827 (PC-7827). In Norway, both PC-7827 and ST-7827 isolates were almost exclusively isolated from men. Phylogeographical analyses demonstrated an Asian origin of the genogroup, with multiple inferred exports to Europe and the USA. The genogroup was uniformly resistant to fluoroquinolones, and associated with reduced susceptibility to both azithromycin and the extended-spectrum cephalosporins (ESCs) cefixime and ceftriaxone. From a genetic background including the penA allele 13.001, associated with reduced ESC susceptibility, we identified repeated events of acquisition of porB alleles associated with further reduction in ceftriaxone susceptibility. Transmission of the strain was significantly reduced in Norway in 2019, but our results indicate the existence of a recently established global reservoir. The worrisome drug-resistance profile and rapid emergence of PC-7827 calls for close monitoring of the situation.

中文翻译:

淋病奈瑟菌分支的突然出现,对超广谱头孢菌素的敏感性降低,挪威

淋病奈瑟菌 多位点序列类型 (ST)-7827 在 2016-2018 年期间在挪威以戏剧性的方式出现。在这里,我们的目标是阐明这个 ST 的起源和扩展。ST-7827 被发现是多系的,但大多数成员属于我们称为 PopPUNK 集群 7827 (PC-7827) 的单系进化枝。在挪威,PC-7827 和 ST-7827 分离株几乎完全从男性中分离出来。系统地理学分析表明该基因组起源于亚洲,推测出口到欧洲和美国。该基因组对氟喹诺酮类药物均具有抗性,并且对阿奇霉素和超广谱头孢菌素 (ESC) 头孢克肟和头孢曲松的敏感性降低。来自包括penA在内的遗传背景等位基因 13.001 与 ESC 易感性降低相关,我们确定了与头孢曲松易感性进一步降低相关的porB等位基因的重复获得事件。2019 年,挪威的菌株传播显着减少,但我们的结果表明,最近建立了一个全球水库。令人担忧的耐药性情况和 PC-7827 的迅速出现要求密切监测情况。
更新日期:2020-12-22
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