Natural products are a valuable source of biologically active compounds and continue to play an important role in modern drug discovery due to their great structural diversity and unique biological properties. Brazilian biodiversity is one of the most extensive in the world and could be an effective source of new chemical entities for drug discovery. Mosquitoes are vectors for the transmission of dengue, Zika, chikungunya, yellow fever, and many other diseases of public health importance. These diseases have a major impact on tropical and subtropical countries, and their incidence has increased dramatically in recent decades, reaching billions of people at risk worldwide. The prevention of these diseases is mainly through vector control, which is becoming more difficult because of the emergence of resistant mosquito populations to the chemical insecticides. Strategies to provide efficient and safe vector control are needed, and secondary metabolites from plant species from the Brazilian biodiversity, especially Cerrado, that are biologically active for mosquito control are herein highlighted. Also, this is a literature revision of targets as insights to promote advances in the task of developing active compounds for vector control. In view of the expansion and occurrence of arboviruses diseases worldwide, scientific reviews on bioactive natural products are important to provide molecular models for vector control and contribute with effective measures to reduce their incidence.

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生物活性巴西植物物种作为寻找蚊子控制分子模型的策略的潜力

天然产物是生物活性化合物的宝贵来源，由于其巨大的结构多样性和独特的生物学特性，在现代药物发现中继续发挥重要作用。巴西生物多样性是世界上最广泛的生物多样性之一，可以成为用于药物发现的新化学实体的有效来源。蚊子是登革热、寨卡病毒、基孔肯雅热、黄热病和许多其他对公共卫生具有重要意义的疾病的传播媒介。这些疾病对热带和亚热带国家产生重大影响，其发病率在近几十年来急剧增加，影响到全球数十亿人。这些疾病的预防主要是通过病媒控制，由于对化学杀虫剂具有抗药性的蚊子种群的出现，这变得越来越困难。需要提供有效和安全的病媒控制的策略，本文强调了来自巴西生物多样性植物物种的次级代谢物，尤其是塞拉多，它们具有生物活性，可用于控制蚊子。此外，这是对目标的文献修订，作为促进开发用于载体控制的活性化合物的任务的见解。鉴于虫媒病毒病在全球范围内的扩大和发生，对生物活性天然产物的科学评价对于提供用于病媒控制的分子模型并有助于采取有效措施降低其发病率具有重要意义。和来自巴西生物多样性植物物种的次生代谢物，特别是塞拉多，在此强调了对蚊子控制具有生物活性。此外，这是对目标的文献修订，作为促进开发用于载体控制的活性化合物的任务的见解。鉴于虫媒病毒病在全球范围内的扩大和发生，对生物活性天然产物的科学评价对于提供用于病媒控制的分子模型并有助于采取有效措施降低其发病率具有重要意义。和来自巴西生物多样性植物物种的次生代谢物，特别是塞拉多，在此强调了对蚊子控制具有生物活性。此外，这是对目标的文献修订，作为促进开发用于载体控制的活性化合物的任务的见解。鉴于虫媒病毒病在全球范围内的扩大和发生，对生物活性天然产物的科学评价对于提供用于病媒控制的分子模型并有助于采取有效措施降低其发病率具有重要意义。