The Resendiz and Wang teams report the base pairing preferences of canonical and modified purine‐based nucleobases within duplexes of RNA. Using circular dichroism and density functional theory, the teams probed the thermal stability and H‐bonding interactions of the purine nucleobases G, I, A, and the corresponding 8‐oxo‐7,8‐dihydropurine and 8‐bromopurine derivatives, 8‐oxoG, 8‐oxoI, 8‐oxoA, 8‐BrG, and 8‐BrI as they form base pairs within an A‐form helix. The data helps aid our understanding of RNA lesions caused by oxidative stress and could be of use in the design of other nucleoside‐based structural motifs or biomaterials. (DOI: 10.1002/bip.23410)

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Resendiz和Wang小组报告了RNA双链体中规范的和修饰的基于嘌呤的核碱基的碱基配对偏好。研究小组使用圆二色性和密度泛函理论研究了嘌呤核碱基G，I，A以及相应的8-oxo-7,8-dihydropurine和8-bromopurine衍生物8-oxoG的热稳定性和H键相互作用。 ，8-oxoI，8-oxoA，8-BrG和8-BrI，因为它们在A型螺旋中形成碱基对。数据有助于我们理解由氧化应激引起的RNA损伤，并且可用于设计其他基于核苷的结构基序或生物材料。（DOI：10.1002 / bip.23410）