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Beyond the dyad: the role of mother and father in newborns’ global DNA methylation during the first month of life—a pilot study
Developmental Psychobiology ( IF 2.2 ) Pub Date : 2020-12-22 , DOI: 10.1002/dev.22072
Gaia Romana Pellicano 1 , Valeria Carola 1, 2 , Silvia Bussone 1 , Marco Cecchini 1 , Renata Tambelli 1 , Carlo Lai 1
Affiliation  

The study aimed to longitudinally explore the effects of parental prenatal attachment and psychopathological symptomatology on neonatal global DNA methylation (5-mC) variation between birth and the first month of life. Eighteen mothers and thirteen fathers were assessed before childbirth (t0) by Perceived Stress Scale (PSS), Prenatal-Attachment Inventory, and Paternal Antenatal Attachment Scale; 48 hr after childbirth (t1) by SCL-90-R; and one month after childbirth (t2) by PSS. At t1 and t2, buccal swabs from parents and newborns were collected. In newborns’ 5-mC and single nucleotide polymorphisms (SNPs) of DAT, MAOA, BDNF, and 5-HTTLPR genes were detected, while in parents only SNPs were measured. At t1, newborns’ 5-mC was negatively associated with maternal psychopathological symptoms, while at t2, newborns’ 5-mC was positively associated with paternal psychopathological symptoms and negatively with paternal prenatal attachment. The variation of newborns’ 5-mC from t1 to t2 was predicted by paternal psychopathological symptoms. No significant correlations among parental SNPs and 5-mC levels were found. Results highlight parent-specific influences on newborn's DNA methylation. At birth, maternal psychological symptoms seem to have an effect on newborns’ 5-mC, while after one month of life, paternal psychological characteristics could have a specific role in modulating the newborns’ epigenetic responses to the environment.

中文翻译:

超越二元组:母亲和父亲在新生儿出生后第一个月的整体 DNA 甲基化中的作用——一项初步研究

该研究旨在纵向探讨父母产前依恋和精神病理学症状对出生和出生后第一个月之间新生儿全基因组 DNA 甲基化 (5-mC) 变异的影响。18 名母亲和 13 名父亲在分娩前 (t0) 通过感知压力量表 (PSS)、产前依恋量表和父亲产前依恋量表进行了评估;SCL-90-R 分娩后 48 小时 (t1);分娩后一个月 (t2) 通过 PSS。在 t1 和 t2,收集父母和新生儿的口腔拭子。在新生儿的 DAT、MAOA、BDNF 和 5-HTTLPR 基因的 5-mC 和单核苷酸多态性 (SNP) 中被检测到,而在父母中仅检测到 SNP。在 t1 时,新生儿的 5-mC 与母亲的精神病理症状呈负相关,而在 t2 时,新生儿的 5-mC 与父亲的精神病理症状呈正相关,与父亲的产前依恋呈负相关。新生儿 5-mC 从 t1 到 t2 的变化由父亲的精神病理学症状预测。未发现亲本 SNP 与 5-mC 水平之间存在显着相关性。结果突出了父母特异性对新生儿 DNA 甲基化的影响。出生时,母亲的心理症状似乎对新生儿的 5-mC 有影响,而一个月后,父亲的心理特征可能在调节新生儿对环境的表观遗传反应中发挥特定作用。未发现亲本 SNP 与 5-mC 水平之间存在显着相关性。结果突出了父母特异性对新生儿 DNA 甲基化的影响。出生时,母亲的心理症状似乎对新生儿的 5-mC 有影响,而一个月后,父亲的心理特征可能在调节新生儿对环境的表观遗传反应中发挥特定作用。未发现亲本 SNP 与 5-mC 水平之间存在显着相关性。结果突出了父母特异性对新生儿 DNA 甲基化的影响。出生时,母亲的心理症状似乎对新生儿的 5-mC 有影响,而一个月后,父亲的心理特征可能在调节新生儿对环境的表观遗传反应中发挥特定作用。
更新日期:2020-12-22
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