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Comparison of germ cell differentiation of rat testis fragments cultured in knockout serum replacement versus Albumax™ I
Birth Defects Research ( IF 2.1 ) Pub Date : 2020-12-21 , DOI: 10.1002/bdr2.1859
Noriko Nakamura 1 , Daniel T Sloper 1
Affiliation  

Spermatogenesis complexity makes reliable in vitro testis model development challenging. Previously, we evaluated an in vitro mouse testis organ culture system for assessing testicular toxicity. However, rat models are commonly used for drug/chemical toxicity testing; therefore, we assessed the effects of media on germ cell differentiation in cultured rat testis fragments.

中文翻译:

在敲除血清替代物中培养的大鼠睾丸片段与 Albumax™ I 的生殖细胞分化比较

精子发生的复杂性使得可靠的体外睾丸模型开发具有挑战性。以前,我们评估了用于评估睾丸毒性的体外小鼠睾丸器官培养系统。然而,大鼠模型通常用于药物/化学毒性测试;因此,我们评估了培养基对培养的大鼠睾丸碎片中生殖细胞分化的影响。
更新日期:2021-03-01
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