Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA‐derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNA_GUA fragmentation at the nexus of an evolutionarily conserved adaptive codon‐based stress response that fine‐tunes translation to restrain growth in human cells.

中文翻译：

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Stressin'和slicin'：应激诱导的tRNA断裂密码子适应翻译以抑制细胞生长

转移 RNA (tRNA) 是在翻译过程中解码遗传信息的中心适配器，长期以来一直被认为是静态细胞成分。然而，tRNA 和 tRNA 衍生片段的动态变化是否对基因调控有积极作用仍然存在争议。在本期杂志中，Huh等人(2020) 强调了酪氨酸 tRNA _GUA断裂与进化上保守的基于密码子的适应性应激反应的关系，该反应可微调翻译以抑制人类细胞的生长。