The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo‐EM structures, and a third model based on partial high‐ and low‐resolution structures, suggest how this is accomplished.

中文翻译：

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EMC的膜蛋白生物发生

内质网 (ER) 膜蛋白复合物 (EMC) 是十多年前在 ER 蛋白稳态的遗传筛选中发现的。EMC 插入具有有限疏水性的跨膜结构域 (TMD)。最近的两个低温 EM 结构，以及基于部分高分辨率和低分辨率结构的第三个模型，表明了这是如何实现的。