Background The cardiac system is a combination of a complex structure, various cells, and versatile specified functions and sophisticated regulatory mechanisms. Moreover, cardiac diseases that encompass a wide range of endogenous conditions, remain a serious health burden worldwide. Recent genome-wide profiling techniques have taken the lead in uncovering a new realm of cell types and molecular programs driving physiological and pathological processes in various organs and diseases. In particular, the emerging technique single-cell RNA sequencing dominates a breakthrough in decoding the cell heterogeneity, phenotype transition, and developmental dynamics in cardiovascular science. Conclusion Herein, we review recent advances in single cellular studies of cardiovascular system and summarize new insights provided by single-cell RNA sequencing in heart developmental sciences, stem-cell researches as well as normal or disease-related working mechanisms.

中文翻译：

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单细胞 RNA 测序：深入解码心脏生物学和心血管疾病

背景心脏系统是复杂结构、多种细胞、多种特定功能和复杂调节机制的组合。此外，涵盖范围广泛的内源性疾病的心脏病仍然是世界范围内严重的健康负担。最近的全基因组分析技术率先揭示了细胞类型和分子程序的新领域，这些细胞类型和分子程序驱动了各种器官和疾病的生理和病理过程。特别是，新兴的单细胞 RNA 测序技术在解码心血管科学中的细胞异质性、表型转变和发育动力学方面取得了重大突破。结论 在此，