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Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges
Journal of Bioactive and Compatible Polymers ( IF 1.7 ) Pub Date : 2020-12-20 , DOI: 10.1177/0883911520981705
Tong Wang 1 , Lintong Yang 1 , Guangfei Wang 1 , Lei Han 1 , Kaili Chen 1 , Ping Liu 1 , Shumin Xu 1 , Dongsheng Li 2 , Zeping Xie 3 , Xiumei Mo 2 , Lei Wang 4 , Haiyue Liang 5 , Xuejie Liu 5 , Shumin Zhang 3 , Yonglin Gao 1
Affiliation  

Dialyzed tilapia skin collagen sponge (DTSCS) and self-assembled tilapia skin collagen sponge (STSCS) were prepared by freeze-drying. The raw components used in the fabrication of DTSCS and STSCS were separated and purified from tilapia fish skin. It is anticipated that these collagen sponges could be developed into medical dressings for hemostasis and wound healing. The aim of the present research was to explore the possibility of DTSCS and STSCS as medical dressings and compare their differences by scanning electron microscopy (SEM), water absorption measurement, differential scanning calorimetry (DSC), measurement of porosity, cytotoxicity, hemolysis, in vivo biocompatibility, and evaluation of hemostatic performance and wound healing. The results indicate that DTSCS and STSCS are suitable materials for use in medical applications with a loose and porous structure, high water absorption, high porosity, and high thermal stability. The materials also displayed good biocompatibility, including excellent blood compatibility, a lack of cytotoxicity, with no apparent rejection following implantation. STSCS exhibited rapid hemostasis and promoted healing, with slightly greater efficacy than DTSCS. The hemostatic properties and promotion of healing in DTSCS was similar to that of commercial bovine collagen sponge. Therefore, DTSCS and STSCS both represented excellent potential candidate materials for use as hemostatic agents and wound dressings.



中文翻译:

罗非鱼皮肤胶原蛋白海绵的生物相容性,止血性能和伤口愈合评估

通过冷冻干燥制备透析的罗非鱼皮肤胶原蛋白海绵(DTSCS)和自组装的罗非鱼皮肤胶原蛋白海绵(STSCS)。从罗非鱼鱼皮中分离和纯化了用于制造DTSCS和STSCS的原料。预期这些胶原蛋白海绵可被开发成用于止血和伤口愈合的医用敷料。本研究的目的是探索DTSCS和STSCS作为医用敷料的可能性,并通过扫描电子显微镜(SEM),吸水率测量,差示扫描量热法(DSC),孔隙率,细胞毒性,溶血性的测量来比较它们之间的差异。体内生物相容性,以及止血性能和伤口愈合的评估。结果表明,DTSCS和STSCS是具有疏松和多孔结构,高吸水率,高孔隙率和高热稳定性的适用于医疗应用的材料。这些材料还表现出良好的生物相容性,包括出色的血液相容性,缺乏细胞毒性,并且在植入后没有明显的排斥反应。STSCS具有快速止血和促进愈合的作用,其功效比DTSCS略强。DTSCS中的止血特性和促进愈合与商用牛胶原海绵相似。因此,DTSCS和STSCS都是用作止血剂和伤口敷料的极好的潜在候选材料。包括出色的血液相容性,缺乏细胞毒性以及植入后无明显排斥反应。STSCS具有快速止血和促进愈合的作用,其功效比DTSCS略强。DTSCS中的止血特性和促进愈合与商用牛胶原海绵相似。因此,DTSCS和STSCS都是用作止血剂和伤口敷料的极好的潜在候选材料。包括出色的血液相容性,缺乏细胞毒性以及植入后无明显排斥反应。STSCS具有快速止血和促进愈合的作用,其功效比DTSCS略强。DTSCS中的止血特性和促进愈合与商用牛胶原海绵相似。因此,DTSCS和STSCS都是用作止血剂和伤口敷料的极好的潜在候选材料。

更新日期:2020-12-21
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