Periploca forrestii Schltr (P. forrestii) is a herb used in traditional Chinese medicine for its anti-rheumatoid arthritis effect. The aim of this study was to compare the pharmacokinetic properties of the 5 active components of this plant: neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid C, and periplocin between normal rats and adjuvant-induced arthritis model rats. After the intravenous administration (177.78 mg/kg) of P. forrestii extract, samples were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. Compared with normal rats, the area under the curve [(AUC)_(0-t), AUC_(0-∞)], mean residence time [(MRT)_(0-t), MRT_(0-∞)] of neochlorogenic acid-treated rats decreased significantly, and drug clearance (CL) and apparent volume of distribution (V) increased significantly; the V of chlorogenic acid-treated rats decreased significantly, and MRT_(0-t) significantly increased; the AUC_(0-t) and AUC_(0-∞) of cryptochlorogenic acid-treated rats decreased significantly, and CL and V increased significantly; the AUC_(0-t) and MRT_(0-t) of isochlorogenic acid C-treated rats decreased significantly, and V increased significantly; the AUC_(0-t) and AUC_(0-∞) of periplocin-treated rats increased significantly, and MRT_(0-t), MRT_(0-∞), CL, and V decreased significantly in model rats. The disease condition of rheumatoid arthritis in rats had a significant effect on the in vivo pharmacokinetics of P. forrestii after the intravenous administration.

Periploca forrestii Schltr（P. forrestii）是一种中草药，具有抗类风湿关节炎的作用。这项研究的目的是比较该植物的5种活性成分的药代动力学特性：新绿原酸，绿原酸，隐绿原酸，异绿原酸C和正常大鼠与佐剂诱发的关节炎模型大鼠之间的粘膜黏蛋白。静脉注射forrestii提取物（177.78 mg / kg）后，通过超高效液相色谱-串联质谱分析样品。与正常大鼠相比，曲线下面积[（AUC）_（0-t），AUC _（0-∞） ]，平均停留时间[（MRT）_（0-t），MRT _（0-∞）新绿原酸处理的大鼠的]显着降低，药物清除率（CL）和表观分布体积（V）显着增加；绿原酸处理大鼠的V明显降低，MRT _（0-t）显着增加；隐绿原酸处理的大鼠的AUC _（0-t）和AUC _（0-∞）显着降低，CL和V显着升高；异绿原酸C处理的大鼠的AUC _（0-t）和MRT _（0-t）显着降低，V显着升高；围肾上腺素治疗的大鼠的AUC _（0-t）和AUC _（0-∞）显着增加，MRT _（0-t），MRT _（0-∞），CL和V在模型大鼠中显着降低。大鼠类风湿关节炎的疾病状况对静脉内给药后福氏疟原虫的体内药代动力学具有显着影响。