Mesenchymal stem cells (MSCs), defined as plastic adherent cells with multipotent differentiation capacity in vitro, are an emerging and valuable tool to treat a plethora of diseases due to their therapeutic mechanisms such as their paracrine activity, mitochondrial and organelle transfer, and transfer of therapeutic molecules via exosomes. Nowadays, there are more than a thousand registered clinical trials related to MSC application around the world, highlighting MSC role on difficult-to-treat high-incidence diseases such as the current COVID-19, HIV infections, and autoimmune and metabolic diseases. Here, we summarize a general overview of MSCs and their therapeutic mechanisms; also, we discuss some of the novel clinical trial protocols and their results as well as a comparison between the number of registries, countries, and search portals.

中文翻译：

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人间充质干细胞：高发病率疾病的当前替代方法，甚至SARS-Cov-2

间充质干细胞（MSCs）被定义为具有体外多能分化能力的塑料贴壁细胞，由于其诸如旁分泌活性，线粒体和细胞器转移以及转移的治疗机制，是治疗多种疾病的新兴且有价值的工具。通过外泌体的治疗分子。如今，全世界有超过一千项与MSC应用相关的注册临床试验，突出了MSC在难以治疗的高发疾病中的作用，例如当前的COVID-19，HIV感染以及自身免疫和代谢性疾病。在这里，我们总结了MSC及其治疗机制的概述。此外，我们还将讨论一些新颖的临床试验方案及其结果，以及注册机构，国家/地区和搜索门户之间的比较。