In this study, we describe novel gallium(III), germanium(IV), and hafnium(IV) folate complexes, including their synthesis and analyses. The synthesized folate complexes were also subject to thermal analysis (TGA) to better examine their thermal degradation and kinetic properties. The folate complexes had high stability and were nonspontaneous. The Coats–Redfern and Horowitz–Metzger equations were used to determine thermodynamic parameters and describe the kinetic properties. These complexes were synthesized through the chemical interactions in neutralized media between the folic acid drug ligand (FAH₂) with GaCl₃, GeCl₄, and HfCl₄ metal salts at 1 : 2 (metal : ligand) molar ratio. The conductance measurements have low values due to their nonelectrolytic behavior. The X-ray powder diffraction solid powder pattern revealed a semicrystalline nature. In vitro, we screened the synthesized folate chelates for antibacterial and antifungal activities. The inhibition of four bacterial and two fungi pathogens (E. coli, B. subtilis, P. aeruginosa, S. aureus, A. flavus, and Candida albicans) was improved using a folic acid drug relative to the control drug.

中文翻译：

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新型镓（III），锗（IV）和Ha（IV）叶酸配合物及其光谱，热分解，形态和生物学特性

在这项研究中，我们描述了新型的镓（III），锗（IV）和ha（IV）叶酸络合物，包括它们的合成和分析。合成的叶酸配合物也要进行热分析（TGA），以更好地检查其热降解和动力学性质。叶酸配合物具有高稳定性并且是非自发的。用Coats–Redfern和Horowitz–Metzger方程确定热力学参数并描述动力学特性。这些配合物是通过叶酸药物配体（FAH ₂）与GaCl ₃，GeCl ₄和HfCl ₄之间的中和介质中的化学相互作用合成的1：2（金属：配体）摩尔比的金属盐。由于其非电解行为，电导测量值较低。X射线粉末衍射固体粉末图案显示出半结晶性质。在体外，我们筛选了合成的叶酸螯合物的抗菌和抗真菌活性。使用叶酸药物相对于对照药物可改善对四种细菌和两种真菌病原体（大肠杆菌，枯草芽孢杆菌，铜绿假单胞菌，金黄色葡萄球菌，黄曲霉和白色念珠菌）的抑制作用。