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The Relationship between Negative Symptoms and Both Emotion Management and Non-social Cognition in Schizophrenia Spectrum Disorders
Journal of the International Neuropsychological Society ( IF 2.6 ) Pub Date : 2020-12-21 , DOI: 10.1017/s1355617720001290
Caitlin O B Yolland 1 , Sean P Carruthers 1, 2 , Wei Lin Toh 1 , Erica Neill 1, 3, 4 , Philip J Sumner 1 , Elizabeth H X Thomas 1, 5 , Eric J Tan 1, 3 , Caroline Gurvich 5 , Andrea Phillipou 1, 3, 4 , Tamsyn E Van Rheenen 1, 2 , Susan L Rossell 1, 3
Affiliation  

Objective:There is ongoing debate regarding the relationship between clinical symptoms and cognition in schizophrenia spectrum disorders (SSD). The present study aimed to explore the potential relationships between symptoms, with an emphasis on negative symptoms, and social and non-social cognition.Method:Hierarchical cluster analysis with k-means optimisation was conducted to characterise clinical subgroups using the Scale for the Assessment of Negative Symptoms and Scale for the Assessment of Positive Symptoms in n = 130 SSD participants. Emergent clusters were compared on the MATRICS Consensus Cognitive Battery, which measures non-social cognition and emotion management as well as demographic and clinical variables. Spearman’s correlations were then used to investigate potential relationships between specific negative symptoms and emotion management and non-social cognition.Results:Four distinct clinical subgroups were identified: 1. high hallucinations, 2. mixed symptoms, 3. high negative symptoms, and 4. relatively asymptomatic. The high negative symptom subgroup was found to have significantly poorer emotion management than the high hallucination and relatively asymptomatic subgroups. No further differences between subgroups were observed. Correlation analyses revealed avolition-apathy and anhedonia-asociality were negatively correlated with emotion management, but not non-social cognition. Affective flattening and alogia were not associated with either emotion management or non-social cognition.Conclusions:The present study identified associations between negative symptoms and emotion management within social cognition, but no domains of non-social cognition. This relationship may be specific to motivation, anhedonia and apathy, but not expressive deficits. This suggests that targeted interventions for social cognition may also result in parallel improvement in some specific negative symptoms.

中文翻译:

精神分裂症谱系障碍负性症状与情绪管理和非社会认知的关系

目的:关于精神分裂症谱系障碍(SSD)的临床症状与认知之间的关系一直存在争议。本研究旨在探讨症状之间的潜在关系,重点是阴性症状与社会和非社会认知。方法:分层聚类分析ķ-使用评估阴性症状的量表和评估阳性症状的量表进行均值优化以表征临床亚组n= 130 名 SSD 参与者。新兴集群在 MATRICS 共识认知电池上进行了比较,该电池测量非社会认知和情绪管理以及人口统计和临床变量。然后使用 Spearman 相关性研究特定阴性症状与情绪管理和非社会认知之间的潜在关系。结果:确定了四个不同的临床亚组:1. 高度幻觉,2. 混合症状,3. 高度阴性症状,和 4.相对无症状。与高度幻觉和相对无症状的亚组相比,高阴性症状亚组的情绪管理明显较差。没有观察到亚组之间的进一步差异。相关分析显示,意志冷漠和快感缺乏社会性与情绪管理呈负相关,但与非社会认知无关。情感扁平化和失语与情绪管理或非社会认知无关。结论:本研究确定了社会认知内的负面症状与情绪管理之间的关联,但没有非社会认知领域。这种关系可能特定于动机、快感缺失和冷漠,但不是表达缺陷。这表明针对社会认知的有针对性的干预也可能导致某些特定阴性症状的平行改善。本研究确定了社会认知中负面症状与情绪管理之间的关联,但没有发现非社会认知领域。这种关系可能特定于动机、快感缺失和冷漠,但不是表达缺陷。这表明针对社会认知的有针对性的干预也可能导致某些特定阴性症状的平行改善。本研究确定了社会认知中负面症状与情绪管理之间的关联,但没有发现非社会认知领域。这种关系可能特定于动机、快感缺失和冷漠,但不是表达缺陷。这表明针对社会认知的有针对性的干预也可能导致某些特定阴性症状的平行改善。
更新日期:2020-12-21
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