Abstract

The present study aims at evaluating potential of the ethanol extracts of L. camara leaves (LE), flowers (FlE) and roots (RE) in the treatment of renal calculi and characterising the secondary metabolites in the active extract. The results revealed that the FlE had significantly reduced the levels of kidney parameters (calcium, creatinine, urea, and uric acid) against ethylene glycol (EG) injuries, and restored the activity of glutathione peroxidase (GPx), superoxide dismutase and lipid peroxide malondialdehyde to the normal level. In addition, FlE significantly attenuated iNOS tissue expression caused by EG. The results obtained in this study suggest the potential value of the L. camara L. flowers as an antiurolithiatic agent.

摘要

本研究旨在评估L. camara叶 (LE)、花 (FlE) 和根 (RE) 的乙醇提取物在治疗肾结石中的潜力，并表征活性提取物中的次级代谢物。结果表明，FlE 显着降低了针对乙二醇 (EG) 损伤的肾脏参数（钙、肌酐、尿素和尿酸）水平，并恢复了谷胱甘肽过氧化物酶 (GPx)、超氧化物歧化酶和脂质过氧化物丙二醛的活性。到正常水平。此外，FlE 显着减弱了由 EG 引起的 iNOS 组织表达。本研究中获得的结果表明L. camara L. 花作为抗尿石剂的潜在价值。