Ischemia impacts multiple organ systems and is the major cause of morbidity and mortality in the developed world. Ischemia disrupts tissue homeostasis, driving cell death, and damages tissue structure integrity. Strategies to heal organs, like the infarcted heart, or to replace cells, as done in pancreatic islet β‐cell transplantations, are often hindered by ischemic conditions. Here, it is discovered that the basement membrane glycoprotein nidogen‐1 attenuates the apoptotic effect of hypoxia in cardiomyocytes and pancreatic β‐cells via the αvβ3 integrin and beneficially modulates immune responses in vitro. It is shown that nidogen‐1 significantly increases heart function and angiogenesis, while reducing fibrosis, in a mouse postmyocardial infarction model. These results demonstrate the protective and regenerative potential of nidogen‐1 in ischemic conditions.

中文翻译：

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Nidogen-1 减轻缺血并促进组织存活和再生

缺血影响多个器官系统，是发达国家发病和死亡的主要原因。缺血会破坏组织稳态，导致细胞死亡，并损害组织结构的完整性。治愈器官（如梗塞的心脏）或更换细胞（如胰岛β细胞移植）的策略通常会受到缺血性疾病的阻碍。在这里，我们发现基底膜糖蛋白 nidogen-1通过α v β 3 整联蛋白减弱心肌细胞和胰腺β细胞缺氧的凋亡作用，并有益地调节体外免疫反应。研究表明，在小鼠心肌梗塞后模型中，nidogen-1 显着增强心脏功能和血管生成，同时减少纤维化。这些结果证明了 nidogen-1 在缺血条件下的保护和再生潜力。