Utility of plant-based materials in tissue engineering has exponentially increased over the years. Recent efforts in this area have been focused on substituting synthetic cross-linkers with natural ones derived from biological sources. These cross-linkers are essentially derived from the vegetative components of plants therefore suitably categorised as ‘green’ and renewable materials. Utilization of plant based cross-linkers in scaffolds and hydrogels offers several advantages compared to the synthetic ones. Natural compounds, like ferulic acid and genipin, when incorporated into scaffolds can promote cellular proliferation and growth, by regulation of growth factors. They participate in crucial activities, thus providing impetus for cell growth, function, differentiation and angiogenesis. Several natural compounds inherently possess anti-microbial, antioxidant and anti-inflammatory effects, which enhance the inherent characteristics of the scaffolds. Versatility of natural cross-linkers can be exploited for diverse applications. Integrating such potent molecules can enable the scaffold to display relevant characteristics for each function. This review article focuses on the recent developments with plant based cross-linkers that are employed for scaffold synthesis and their applications, which may be explored to synthesize scaffolds suitable for diverse biomedical applications.

多年来，植物基材料在组织工程中的应用呈指数级增长。该领域最近的努力集中在用源自生物来源的天然交联剂代替合成交联剂。这些交联剂主要来源于植物的营养成分，因此被适当地归类为“绿色”和可再生材料。与合成交联剂相比，在支架和水凝胶中使用基于植物的交联剂具有几个优点。天然化合物，如阿魏酸和京尼平，当结合到支架中时，可以通过调节生长因子促进细胞增殖和生长。它们参与关键活动，从而为细胞生长、功能、分化和血管生成提供动力。几种天然化合物固有地具有抗微生物、抗氧化和抗炎作用，从而增强了支架的固有特性。天然交联剂的多功能性可用于多种应用。整合这些有效分子可以使支架显示出每种功能的相关特征。这篇综述文章重点介绍了用于支架合成的植物交联剂的最新发展及其应用，可探索合成适用于各种生物医学应用的支架。整合这些有效分子可以使支架显示出每种功能的相关特征。这篇综述文章重点介绍了用于支架合成的植物交联剂的最新发展及其应用，可探索合成适用于各种生物医学应用的支架。整合这些有效分子可以使支架显示出每种功能的相关特征。这篇综述文章重点介绍了用于支架合成的植物交联剂的最新发展及其应用，可探索合成适用于各种生物医学应用的支架。