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Genetic correlations between COVID-19 and a variety of diseases and other medically relevant traits
medRxiv - Genetic and Genomic Medicine Pub Date : 2020-12-20 , DOI: 10.1101/2020.12.18.20248319
Xiao Chang , Yun Li , Kenny Nguyen , Huiqi Qu , Yichuan Liu , Joseph Glessner , Patrick M A Sleiman , Hakon Hakonarson

We analyzed GWAS results released by COVID-19 Host Genetics Initiative, UK biobank and GWAS Catalog to explore the genetic overlap between COVID-19 and a broad spectrum of traits and diseases. We validate previously reported medical conditions and risk factors based on epidemiological studies, including but not limited to hypertension, type 2 diabetes and obesity. We also report novel traits associated with COVID-19, which have not been previously reported from epidemiological data, such as opioid use and educational attainment. Taken together, this study extends our understanding of the genetic basis of COVID-19, and provides target traits for further epidemiological studies.

中文翻译:

COVID-19与多种疾病和其他医学相关性状之间的遗传相关性

我们分析了COVID-19宿主遗传学计划,英国生物库和GWAS目录发布的GWAS结果,以探索COVID-19与广泛的性状和疾病之间的遗传重叠。我们根据流行病学研究(包括但不限于高血压,2型糖尿病和肥胖症)验证了先前报道的医学状况和危险因素。我们还报告了与COVID-19相关的新特征,以前从未从流行病学数据中报告过这些新特征,例如阿片类药物的使用和受教育程度。两者合计,这项研究扩展了我们对COVID-19遗传基础的理解,并为进一步的流行病学研究提供了目标特征。
更新日期:2020-12-21
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