Medicinal plants have always been utilized for the prevention and treatment of the spread of different diseases all around the world. To name some traditionalmedicine that has been used over centuries, we can refer to phytochemicals such as naringin, icariin, genistein, and resveratrol gained from plants. Osteogenic differentiation andmineralization of stem cells can be the result of specific bioactive compounds fromplants. One of the most appealing choices for therapy can be mesenchymal stem cells (MSCs) because it has a great capability of self‐renewal and differentiation into three descendants, namely, endoderm, mesoderm, and ectoderm. Stem cell gives us the glad tidings of great advances in tissue regeneration and transplantation field for treatment of diseases. Using plant bioactive phytochemicals also holds tremendous promises in treating diseases such as osteoporosis. The purpose of the present review article thus is to investigate what are the roles and consequences of phytochemicals on osteogenic differentiation of MSCs.

药用植物一直被用于预防和治疗全世界各种疾病的传播。为了列举一些已经使用了数百年的传统医学，我们可以指植物化学物质，如柚皮苷，柠檬素，染料木黄酮和从植物中获得的白藜芦醇。干细胞的成骨分化和矿化作用可能是来自植物的特定生物活性化合物的结果。间充质干细胞（MSCs）是最吸引人的治疗选择之一，因为它具有自我更新和分化为内胚层，中胚层和外胚层三个后代的强大能力。干细胞为我们提供了在组织再生和移植领域治疗疾病方面取得重大进展的令人欣喜的消息。在治疗骨质疏松症等疾病中，使用植物生物活性植物化学成分也具有广阔的前景。因此，本综述文章的目的是研究植物化学物质对MSC成骨分化的作用和后果。