Sutures, staples, clips, and skin closure strips are used as the gold standard to close wounds after an injury. In spite of being the present standard of care, the utilization of these conventional methods is precarious amid complicated and sensitive surgeries such as vascular anastomosis, ocular surgeries, nerve repair, or due to the high-risk components included. Tissue adhesives function as an interface to connect the surfaces of wound edges and prevent them from separation. They are fluid or semi-fluid mixtures that can be easily used to seal any wound of any morphology-uniform or irregular. As such, they provide alternatives to new and novel platforms for wound closure methods. In this review, we offer a background on the improvement of distinctive tissue adhesives focusing on the chemistry of some of these products that have been a commercial success from the clinical application perspective. This review is aimed to provide a guide toward the innovation of tissue bioadhesive materials and their associated biomedical applications.

中文翻译：

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组织粘合剂：从研究到临床转化

缝合线、U形钉、夹子和皮肤闭合条被用作受伤后闭合伤口的黄金标准。尽管是目前的护理标准，但在血管吻合、眼部手术、神经修复等复杂且敏感的手术中，或者由于其中包含高风险成分，这些传统方法的使用是不稳定的。组织粘合剂充当连接伤口边缘表面并防止它们分离的界面。它们是流体或半流体混合物，可轻松用于密封任何形态的伤口（均匀或不规则）。因此，它们为伤口闭合方法提供了新的平台的替代方案。在这篇综述中，我们提供了独特的组织粘合剂改进的背景，重点关注其中一些产品的化学成分，从临床应用的角度来看，这些产品已经取得了商业上的成功。本综述旨在为组织生物粘附材料及其相关生物医学应用的创新提供指导。