ABSTRACT

The utility of a non-linear mixed effects model to model heart rate is examined. The heart rate acceleration is derived as a parameter from this model. The relationship between different potential measures of disease severity including heart rate acceleration is examined. Our study is focused on heart rate variability (HRV), heart rate acceleration (HRA), oxygen saturation (SaO2) and the six-minute walk distance (6MWD) as well as their relationship to WHO functional class. The results and conclusions are derived from data were collected by the Children Hospital of Colorado.

中文翻译：

---

肺动脉高压心率与功能分级关系的探讨

摘要

检查了非线性混合效应模型对心率建模的效用。心率加速度作为该模型的参数导出。检查了包括心率加速在内的疾病严重程度的不同潜在度量之间的关系。我们的研究侧重于心率变异性 (HRV)、心率加速 (HRA)、氧饱和度 (SaO2) 和六分钟步行距离 (6MWD) 以及它们与 WHO 功能等级的关系。结果和结论来自科罗拉多儿童医院收集的数据。