Abstract Exposure to stress during the course of a lifetime is inevitable in the animal kingdom. It is the response to stress, the valence of the exposure and the developmental time point that largely determine the consequences to the initial and subsequent exposures. The versatility of transcriptomic methods to yield rich, high resolution, information laden datasets from entire brain regions to single cells makes it a powerful approach to investigate the effects of stress from several angles. Dysregulation of the transcriptome is now a phenotypic signature of many neuropsychiatric disorders. New insight has been gained from examining stress-induced changes in gene expression at a global scale. Human postmortem datasets from depression and posttraumatic stress disorder studies have identified major gene expression changes in the diseased brain including sex-specific changes and marked differences in male and female molecular profiles for the same disorder. Extensions of this work into animal models has explored the impact of transcriptomic dysregulation on early life stress, chronic and transgenerational impact of stress. Here we explore the findings of human postmortem genomic studies of neuropsychiatric disorders and comparable animal models through the lens of transcriptomic dysregulation and how these findings have contributed to our understanding of stress.

中文翻译：

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压力及其对转录组的影响

摘要 在动物王国中，一生中的压力是不可避免的。对压力的反应、暴露的效价和发育时间点在很大程度上决定了初始和后续暴露的后果。转录组学方法的多功能性可以产生从整个大脑区域到单个细胞的丰富、高分辨率、充满信息的数据集，使其成为从多个角度研究压力影响的有力方法。转录组的失调现在是许多神经精神疾病的表型特征。通过在全球范围内检查压力引起的基因表达变化，获得了新的见解。来自抑郁症和创伤后应激障碍研究的人类死后数据集已经确定了患病大脑中的主要基因表达变化，包括性别特异性变化以及同一疾病的男性和女性分子谱的显着差异。将这项工作扩展到动物模型，探索了转录组失调对早期生活压力、压力的慢性和跨代影响的影响。在这里，我们通过转录组失调的镜头探索人类死后基因组研究对神经精神疾病和类似动物模型的发现，以及这些发现如何有助于我们对压力的理解。将这项工作扩展到动物模型，探索了转录组失调对早期生活压力、压力的慢性和跨代影响的影响。在这里，我们通过转录组失调的镜头探索人类死后基因组研究对神经精神疾病和类似动物模型的发现，以及这些发现如何有助于我们对压力的理解。将这项工作扩展到动物模型，探索了转录组失调对早期生活压力、压力的慢性和跨代影响的影响。在这里，我们通过转录组失调的镜头探索人类死后基因组研究对神经精神疾病和类似动物模型的发现，以及这些发现如何有助于我们对压力的理解。