Ethanol can have both an aversive and rewarding effect, which may have a significant relationship to its individual preference. So far, the reasons for the high and low ethanol preference in the WHP (Warsaw High Preferring) and WLP (Warsaw Low Preferring) lines have not been found. WHP rats spontaneously drink over 5 g/kg/day of ethanol, while WLP rats drink under 2 g/kg/day. The purpose of the work was to study the sensitivity of WHP and WLP rats to the aversive effects of ethanol at doses of 1.5 g/kg and 2.0 g/kg in the conditioned taste aversion (CTA) procedure. Lower doses (0.5 and 1.0 g/kg, i.p.) were tested earlier and only 1.0 g/kg produced a slight aversion in WLP rats. The secondary aim was to check the additional potential factors (blood ethanol concentration, pain sensitivity, anxiety-related behaviour, learning, and memory) that may constitute an important differentiating feature of the WHP and WLP lines. For this purpose, the following tests were conducted: blood ethanol concentration, novel object recognition (NOR), flinch-jump, hot-plate, and elevated plus maze (EPM).

The 1.5 g/kg i.p. dose of ethanol caused the development of an aversion only in WLP rats and the aversion extinguished in the post-conditioning phase. The 2.0 g/kg i.p. dose of ethanol resulted in the development of an aversion in both the tested groups, with the aversion being maintained throughout the whole post-conditioning period only in the WLP rats. There were no differences between the lines in terms of the blood ethanol concentration and the EPM tests. WHP rats had a higher pain sensitivity compared to WLP rats in flinch-jump and hot-plate tests. WLP rats showed a shorter exploration time for both objects compared to WHP in the NOR test.

In conclusion, WHP and WLP rats differ in sensitivity to the aversive effects of ethanol. This difference may partially explain their opposite ethanol preference.

乙醇可以产生厌恶和奖励的效果，这可能与其个人偏好有显着关系。目前，WHP（Warsaw High Preferring）和WLP（Warsaw Low Preferring）线中乙醇偏高和偏低的原因尚未找到。WHP 大鼠自发饮用超过 5 g/kg/天的乙醇，而 WLP 大鼠饮用低于 2 g/kg/天。这项工作的目的是研究 WHP 和 WLP 大鼠对 1.5 g/kg 和 2.0 g/kg 剂量的乙醇在条件性味觉厌恶 (CTA) 程序中的厌恶作用的敏感性。较早测试了较低剂量（0.5 和 1.0 g/kg，ip），仅 1.0 g/kg 在 WLP 大鼠中产生轻微的反感。次要目的是检查其他潜在因素（血液乙醇浓度、疼痛敏感性、焦虑相关行为、学习、和内存），这可能构成 WHP 和 WLP 线的重要区别特征。为此，进行了以下测试：血液乙醇浓度、新物体识别 (NOR)、退缩跳跃、热板和高架十字迷宫 (EPM)。

1.5 g/kg ip 剂量的乙醇仅在 WLP 大鼠中引起厌恶的发展，并且厌恶在后适应阶段消失。2.0 g/kg ip 剂量的乙醇导致两个测试组都产生了厌恶感，只有 WLP 大鼠在整个后适应期间都保持了厌恶感。在血液乙醇浓度和 EPM 测试方面，两条线之间没有差异。在退缩跳跃和热板试验中，与 WLP 大鼠相比，WHP 大鼠具有更高的疼痛敏感性。在 NOR 测试中，与 WHP 相比，WLP 大鼠对这两个物体的探索时间更短。

总之，WHP 和 WLP 大鼠对乙醇的厌恶作用的敏感性不同。这种差异可能部分解释了他们相反的乙醇偏好。