Understanding the relationship between the changes in the axonal transport of the optic nerve (ON) and lamina cribrosa (LC) deformation will be helpful to estimate the degree of axonal transport block by measuring the LC deformation in vivo. First, the changes in the axonal transport of the ON were studied using an acute high intraocular pressure (IOP) model, which was established by perfusing saline water into the anterior chamber of cats. The IOP of cat was unilaterally elevated to and maintained at 30, 40, and 50[Formula: see text]mmHg. The axonal transport of the ON was examined by confocal laser scanning microscope. Then the deformations and stress distributions of the LC and ON were calculated using a three-dimensional finite element model of the LC microstructure including ON. The results showed axonal transport changes of ON increased with elevation of the IOPs. While Young’s modulus of the LC and ON were assumed as 0.1[Formula: see text]MPa and 0.03[Formula: see text]MPa, the numerical simulation results showed that LC had displacements of 0.02, 0.03, and 0.04[Formula: see text]mm backward at the IOPs of 30, 40, and 50[Formula: see text]mmHg, respectively. The calculated compressive strain applied to the ON were 0.0425, 0.0567, and 0.0709 under 30, 40, and 50[Formula: see text]mmHg IOP, respectively. The results of strain and stress analysis of LC and ON showed that the deformation of LC would compress the ON. The axonal transport abnormalities could be inferred by measuring the LC deformation in vivo.

中文翻译：

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筛板变形对视神经轴突运输变化的推论

了解视神经 (ON) 轴突运输变化与筛板 (LC) 变形之间的关系将有助于通过测量体内 LC 变形来估计轴突运输阻滞的程度。首先，使用急性高眼压 (IOP) 模型研究 ON 轴突运输的变化，该模型是通过将盐水灌注到猫的前房中建立的。猫眼压单侧升高并维持在30、40、50[公式：见正文]mmHg。通过共聚焦激光扫描显微镜检查ON的轴突运输。然后使用包括ON的LC微观结构的三维有限元模型计算LC和ON的变形和应力分布。结果表明，随着 IOPs 的升高，ON 的轴突运输变化增加。假设LC和ON的杨氏模量分别为0.1[公式：见正文]MPa和0.03[公式：见正文]MPa，数值模拟结果表明，LC的位移分别为0.02、0.03和0.04[公式：见正文] ]mm 在 IOP 分别为 30、40 和 50 [公式：见文本]mmHg 时向后移动。在 30、40 和 50 [公式：见正文]mmHg IOP 下，计算的施加到 ON 的压缩应变分别为 0.0425、0.0567 和 0.0709。LC和ON的应变和应力分析结果表明，LC的变形会压缩ON。轴突运输异常可以通过测量体内 LC 变形来推断。03[公式：见文]MPa，数值模拟结果表明，LC在30、40、50的IOPs处向后位移0.02、0.03、0.04[公式：见文]mm[公式：见文]mmHg ， 分别。在 30、40 和 50 [公式：见正文]mmHg IOP 下，计算的施加到 ON 的压缩应变分别为 0.0425、0.0567 和 0.0709。LC和ON的应变和应力分析结果表明，LC的变形会压缩ON。轴突运输异常可以通过测量体内 LC 变形来推断。03[公式：见文]MPa，数值模拟结果表明，LC在30、40、50的IOPs处向后位移0.02、0.03、0.04[公式：见文]mm[公式：见文]mmHg ， 分别。在 30、40 和 50 [公式：见正文]mmHg IOP 下，计算的施加到 ON 的压缩应变分别为 0.0425、0.0567 和 0.0709。LC和ON的应变和应力分析结果表明，LC的变形会压缩ON。轴突运输异常可以通过测量体内 LC 变形来推断。0709 分别在 30、40 和 50 [公式：见正文]mmHg IOP 下。LC和ON的应变和应力分析结果表明，LC的变形会压缩ON。轴突运输异常可以通过测量体内 LC 变形来推断。0709 分别在 30、40 和 50 [公式：见正文]mmHg IOP 下。LC和ON的应变和应力分析结果表明，LC的变形会压缩ON。轴突运输异常可以通过测量体内 LC 变形来推断。