Coumarin-linked heterocycles represent privileged structural subunits and are welldistributed in naturally occurring compounds with immense biological activities. Multicomponent reactions (MCRs) are becoming a valuable tool for synthesizing structurally diverse molecular entities. On the other hand, the last year has seen a tremendous outburst in modifying chemical processes to make them sustainable for the betterment of our environment. The application of aqueous medium in organic synthesis is fulfilling some of the goals of ‘green and sustainable chemistry’ as it has some advantages over the traditional synthetic methods in terms of reaction rates, yields, purity of the products, product selectivity, etc. Hence, significant progress has been made in recent years. In the present review, we provide an overview of the recent developments of multicomponent synthesis of biologically relevant coumarin linked and fused heterocyclic compounds carried out from 2015 till today in an aqueous medium.

香豆素连接的杂环代表特权结构亚基，并在具有巨大生物活性的天然化合物中分布良好。多组分反应（MCR）成为合成结构多样的分子实体的重要工具。另一方面，去年在改变化学过程以使其可持续发展以改善环境方面取得了巨大的成功。在有机合成中使用水性介质可实现“绿色和可持续化学”的某些目标，因为它在反应速率，产率，产物纯度，产物选择性等方面均优于传统的合成方法。 ，近年来取得了重大进展。在目前的评论中，