Background: Component-resolved diagnosis reveals the IgE response to many inhaled, food, and other allergens, improving the understanding and diagnosis of allergic diseases. Objective: The aims of the study are to study the recognition of different lipid transfer proteins (LTPs) and other allergen families in a large group of people sensitized to Pru p 3 and to analyze the relationship between the clinical entities and the allergens. Methods: This cross-sectional study included a large cohort of patients with positive skin tests to peach fruit and Pru p 3 specific IgE antibodies. Respiratory and food allergy symptoms were collected, and we performed prick tests with pollen, plant food, and other allergens plus the ImmunoCAP ISAC assay. Results: Our sample consisted of 421 people with a mean age of 33.25 years (range 16–68); 54.6% were women. Clinical entities included anaphylaxis (37.1%), urticaria (67.9%), and oral allergy syndrome (59.1%). Rhinitis, rhinoconjunctivitis, and/or asthma were diagnosed in 71.8% of the participants. The most pronounced correlation existed between sensitization to Pru p 3 and to Jug r 3, Pla a 3, Ara h 9, and Cor a 8. We found a higher incidence of anaphylaxis in people with 5 or more recognized LTPs. No association was observed between inhaled and food allergies. Conclusion: Most Pru p 3-sensitized participants were sensitized to additional allergens from the same family and, to a lesser extent, to other allergens, mainly in the profilin and PR-10 protein families. Anaphylaxis occurred in more than a third of the cases evaluated, and almost three-quarters of them had respiratory symptoms. Respiratory and food allergies involving LTPs do not seem to be associated.
Int Arch Allergy Immunol

中文翻译：

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脂质转移蛋白致敏：Pru p 3 致敏患者的过敏反应风险和分子致敏特征

背景：成分解析诊断揭示了对许多吸入性、食物和其他过敏原的 IgE 反应，提高了对过敏性疾病的理解和诊断。目的：本研究的目的是研究对 Pru p 3 敏感的一大群人中不同脂质转移蛋白 (LTP) 和其他过敏原家族的识别，并分析临床实体与过敏原之间的关系。方法：这项横断面研究包括一大群桃子皮试和 Pru p 3 特异性 IgE 抗体呈阳性的患者。收集了呼吸道和食物过敏症状，我们对花粉、植物性食物和其他过敏原进行了点刺试验，并进行了 ImmunoCAP ISAC 检测。结果：我们的样本由 421 人组成，平均年龄为 33.25 岁（范围 16-68）；54.6% 是女性。临床实体包括过敏反应 (37.1%)、荨麻疹 (67.9%) 和口腔过敏综合征 (59.1%)。71.8% 的参与者被诊断出鼻炎、鼻结膜炎和/或哮喘。对 Pru p 3 和 Jug r 3、Pla a 3、Ara h 9 和 Cor a 8 的敏感性之间存在最显着的相关性。我们发现具有 5 个或更多公认 LTP 的人群过敏反应的发生率更高。未观察到吸入性过敏和食物过敏之间存在关联。结论：大多数 Pru p 3 致敏的参与者对来自同一家族的其他过敏原敏感，并在较小程度上对其他过敏原敏感，主要是 profilin 和 PR-10 蛋白家族。超过三分之一的评估病例发生过敏反应，其中近四分之三有呼吸道症状。涉及 LTP 的呼吸和食物过敏似乎没有关联。
Int Arch 过敏免疫