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Are cerebral and behavioural lateralization related to anxiety-like traits in the animal model zebrafish (Danio rerio)?
Laterality ( IF 2.167 ) Pub Date : 2020-12-17 , DOI: 10.1080/1357650x.2020.1854280
Maria Elena Miletto Petrazzini 1, 2 , Linda Gambaretto 3 , Marco Dadda 3 , Caroline Brennan 2 , Christian Agrillo 3, 4
Affiliation  

ABSTRACT

Brain lateralization refers to hemispheric asymmetries in functions and/or neuroanatomical structures. Functional specialization in non-human animals has been mainly inferred through observation of lateralized motor responses and sensory perception. Only in a few cases has the influence of brain asymmetries on behaviour been described. Zebrafish has rapidly become a valuable model to investigate this issue as it displays epithalamic asymmetries that have been correlated to some lateralized behaviours. Here we investigated the relation between neuroanatomical or behavioural lateralization and anxiety using a light-dark preference test in adult zebrafish. In Experiment 1, we observed how scototaxis response varied as a function of behavioural lateralization measured in the detour task as turning preference in front of a dummy predator. In Experiment 2, foxD3:GFP transgenic adult zebrafish with left or right parapineal position, were tested in the same light-dark test as fish in Experiment 1. No correlation was found between the behaviour observed in the detour test and in the scototaxis test nor between the left- and right-parapineal fish and the scototaxis response. The consistency of results obtained in both experiments indicates that neither behavioural nor neuroanatomical asymmetries are related to anxiety-related behaviours measured in the light-dark test.



中文翻译:

脑和行为偏侧化与动物模型斑马鱼(Danio rerio)中的焦虑样特征有关吗?

摘要

脑侧化是指功能和/或神经解剖结构的半球不对称。非人类动物的功能专业化主要是通过观察侧向运动反应和感觉知觉来推断的。仅在少数情况下,描述了大脑不对称对行为的影响。斑马鱼已迅速成为研究此问题的有价值的模型,因为它显示出与某些侧向行为相关的上丘脑不对称性。在这里,我们使用成年斑马鱼的明暗偏好测试研究了神经解剖学或行为偏侧化与焦虑之间的关系。在实验1中,我们观察到绕反应如何随varied回任务中的假人掠食者转弯偏好而随行为偏侧行为的变化而变化。在实验2中,在与实验1中的鱼相同​​的明暗测试中测试了具有左或右副脚踝位置的foxD3:GFP转基因成年斑马鱼。在左,右副臂鱼和尾轴反应之间。在两个实验中获得的结果的一致性表明,行为和神经解剖学上的不对称都与在明暗测试中测得的焦虑相关行为无关。

更新日期:2020-12-17
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