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Effects of Lupron and surgical castration on fecal androgen metabolite concentrations and intermale aggression in capybaras ( Hydrochoerus hydrochaeris )
Zoo Biology ( IF 1.3 ) Pub Date : 2020-12-18 , DOI: 10.1002/zoo.21586
Jennifer H. Yu 1 , Janine Brown 2 , Nicole Boisseau 2 , Tony Barthel 3 , Suzan Murray 1
Affiliation  

To curb agonistic interactions in a bachelor group of three male capybaras (Hydrochoerus hydrochaeris), a single dose of leuprolide acetate (Lupron®) was used in an attempt to chemically sterilize the males. Concurrently, fecal androgen metabolite (FAM) concentrations were quantified via enzyme immunoassay to monitor changes in testosterone production after injection of the gonadotropin-releasing hormone agonist. When Lupron proved ineffective in suppressing intraspecific aggression, surgical castration was performed on two males, with continued noninvasive endocrine monitoring. In all three capybaras, FAM concentrations increased initially as a result of the luteinizing hormone surge, but then decreased significantly following chemical sterilization. Surgical castration resulted in further, persistent declines in FAM concentrations in two males, while the third, intact male demonstrated a rise in FAM to pre-Lupron concentrations at 8.5 and 9.5-month postadministration. Despite successful suppression of sperm and testosterone production, intermale aggression continued, ultimately necessitating separation of the animals and transfer to other holding institutions. Under this set of conditions, a single Lupron dose was inadequate for suppressing intraspecific aggression in a group of three males with a pre-established history of aggression.

中文翻译:

Lupron和手术去势对水豚(Hydrochoerus hydrochaeris)粪便雄激素代谢物浓度和雄性间攻击性的影响

为了抑制由三只雄性水豚 (Hydrochoerus hydrochaeris) 组成的单身汉群体中的激动相互作用,使用单剂量的醋酸亮丙瑞林 (Lupron®) 试图对雄性进行化学消毒。同时,粪便雄激素代谢物 (FAM) 浓度通过酶免疫测定进行量化,以监测注射促性腺激素释放激素激动剂后睾酮产生的变化。当 Lupron 被证明对抑制种内攻击无效时,对两只雄性进行了手术去势,并持续进行无创内分泌监测。在所有三只水豚中,FAM 浓度最初因促黄体激素激增而增加,但在化学灭菌后显着下降。手术阉割导致两名男性的 FAM 浓度进一步持续下降,而第三个完整的雄性在给药后 8.5 和 9.5 个月时表现出 FAM 升高至 Lupron 前的浓度。尽管成功抑制了精子和睾丸激素的产生,雄性间的侵略仍在继续,最终需要将动物分离并转移到其他饲养机构。在这组条件下,单次 Lupron 剂量不足以抑制一组具有预先确定的侵略历史的三名男性的种内侵略。
更新日期:2020-12-18
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