Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.

中文翻译：

---

啮齿动物模型和人类的子宫收缩

异常子宫收缩可导致早产和其他分娩并发症，并且是孕产妇发病率和死亡率的重要原因。为了研究子宫收缩功能障碍的潜在机制，研究人员使用了实验上易于处理的小动物模型。然而，人类和啮齿动物之间的生物学差异改变了研究人员选择动物模型和解释结果的方式。在这里，我们对小鼠、大鼠、豚鼠和人类的子宫兴奋和收缩研究进行了总体回顾，以期向该领域介绍新的研究人员，并帮助设计和解释啮齿动物模型的实验。