In the dark path of tumorigenesis, the more carefully the cancer biology is studied, the more brilliant answers could be given to the countless questions about its orchestrating derivers. The identification of the correlation between Toll‐like receptors (TLRs) and different processes involved in carcinogenesis was one of the single points of blinding light highlighting the interconnection between the immune system and cancer. TLRs are a wide family of single‐pass membrane‐spanning receptors that have developed through the evolution to recognize the structurally conserved molecules derived from microorganisms or damaged cells. But this is not everything about these receptors as they could orchestrate several downstream signalling pathways leading to the formation or suppression of cancer cells. The present review is tempted to provide a concise schematic about the biology and the characters of TLRs and also summarize the major findings of the regulatory role of TLRs and their associated signalling in the pathogenesis of human cancers.

中文翻译：

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Toll 样受体 (TLR)：一个古老的免疫受体家族，在癌症发病机制中具有新的面貌

在肿瘤发生的黑暗道路上，对癌症生物学的研究越仔细，关于其协调衍生者的无数问题就可以给出更精彩的答案。确定 Toll 样受体 (TLR) 与涉及致癌作用的不同过程之间的相关性是突出免疫系统与癌症之间相互联系的致盲光的单点之一。TLR 是一个广泛的单次跨膜受体家族，通过进化发展来识别源自微生物或受损细胞的结构保守分子。但这并不是这些受体的全部，因为它们可以协调几个下游信号通路，导致癌细胞的形成或抑制。