Metastasis is a major challenge in the treatment of cancer. Exosomes are a class of small extracellular vesicles (EVs) that play critical roles in several human diseases, especially cancer, by transferring information (e.g., DNA, RNA, and protein) via cell-to-cell communication. Numerous recent studies have shown that exosomal long non-coding RNAs (lncRNAs) play crucial regulatory roles in cancer metastasis in the tumor microenvironment by altering the expression of several key signaling pathways and molecules. Due to their specificity and sensitivity, exosomal lncRNAs have potential as novel tumor markers and therapeutic targets in the treatment of cancer metastasis. In this review, we aim to summarize the roles of exosomal lncRNAs in cancer metastasis, the mechanisms underlying their roles, and their potential clinical applications.

转移是癌症治疗的主要挑战。外泌体是一类小的细胞外囊泡 (EV)，通过细胞间通讯传递信息（例如 DNA、RNA 和蛋白质），在多种人类疾病，尤其是癌症中发挥关键作用。最近的许多研究表明，外泌体长链非编码 RNA（lncRNA）通过改变几个关键信号通路和分子的表达，在肿瘤微环境中的癌症转移中发挥着至关重要的调节作用。由于其特异性和敏感性，外泌体 lncRNA 具有作为治疗癌症转移的新型肿瘤标志物和治疗靶点的潜力。在这篇综述中，我们旨在总结外泌体 lncRNA 在癌症转移中的作用、其作用的潜在机制及其潜在的临床应用。