A variety of reconsolidation boundary conditions exist for the destabilization of memory, including memory strength, prediction error, trace dominance, and memory age. The vast majority of studies examining boundary conditions have employed aversive tasks. The current study expands the literature on reconsolidation boundary conditions by employing an appetitive odor discrimination task and a delay that exceeds those used in past studies (i.e., 72 days). Rats were trained to dig in cups of scented sand to retrieve a sweet cereal reward. One day (Recent) or 72 days (Remote) following acquisition, rats received a single reactivation trial that included a prediction error (in the form of a non-reinforced trial), followed by intraperitoneal administration of the protein synthesis inhibitor cycloheximide (CHX; 1 mg/kg) or a saline control (SAL). One week later, rats completed a single non-reinforced test trial. Results showed that rats in the Remote condition took longer to dig than those in the Recent condition; additionally, CHX disrupted memory for digging behavior at significant levels in both the Recent and Remote conditions. Results are consistent with a small number of studies using non-aversive tasks, as well as a large number of studies using aversive tasks, demonstrating that recent and remote memories are vulnerable to the effects of an amnesic agent after sufficient reactivation.

存在多种用于破坏存储器稳定性的重新整合边界条件，包括存储器强度，预测误差，迹线优势和存储器寿命。检查边界条件的绝大多数研究都采用了厌恶性任务。当前的研究通过采用具有吸引力的气味识别任务和超过过去研究（即72天）所使用的延迟，扩展了重新整合边界条件的文献。对大鼠进行了训练，以挖出杯中的香沙，以获取甜味麦片奖励。采集后一天（最近）或72天（远程），大鼠接受了一项包含预测错误的复活试验（以非强化试验的形式），然后腹膜内给予蛋白质合成抑制剂环己酰亚胺（CHX; 1 mg / kg）或生理盐水对照（SAL）。一周后，大鼠完成了一项非强化试验。结果表明，处于“偏远”状态的大鼠比“最近”状态的大鼠需要更长的挖掘时间；此外，CHX在“最近”和“远程”条件下都破坏了用于显着行为的挖掘行为。结果与少量使用非算术任务的研究以及大量使用厌恶任务的研究一致，这表明充分激活后，近期和远程记忆易受遗忘剂的影响。