Cognitive bias modification-interpretation (CBM-I) is a promising treatment modality for emotional disorders. But the moderate effect sizes emphasize the need to explore the potential mechanism of the CBM-I. Recent research has identified intolerance of uncertainty (IU) as a possible a trans-diagnostic risk and maintaining factor emotional disorders. The current study investigated the impact of a four-session IU-focused CBM-I on reduction of anxiety and determined whether IU mediated the relationship between IU interpretation bias and anxiety. 40 participants selected based on a high IU interpretation bias (IU-IB) were randomly assigned to an active (IU CBM-I) condition and a control CBM-I condition. By longitudinal design, anxiety and uncertainty questionnaires were administered before, after and one month after the intervention. Multilayer linear model analysis indicated that the active IU CBM-I was significantly associated with changes in anxiety from pre-to-post intervention as well as reductions in IU at post-intervention and month-one follow-up. The results also found that IU mediated the relationship between IU interpretation bias and anxiety.

认知偏差修饰解释（CBM-I）是一种有前途的情绪障碍治疗方法。但是适度的效应大小强调需要探索CBM-I的潜在机制。最近的研究已将不确定性（IU）的不耐受性确定为可能的跨诊断风险和维持因素的情感障碍。当前的研究调查了四阶段以IU为中心的CBM-1对减轻焦虑的影响，并确定了IU是否介导了IU解释偏差和焦虑之间的关系。基于高IU解释偏见（IU-IB）选择的40名参与者被随机分配到活动（IU CBM-1）病情和对照CBM-1病情。通过纵向设计，在干预前，干预后和干预后一个月进行焦虑和不确定性问卷调查。多层线性模型分析表明，活动性IU CBM-I与干预前后焦虑的变化显着相关，以及干预后和一个月随访时IU降低。结果还发现，IU介导了IU解释偏向与焦虑之间的关系。