Autoimmunity to chitinase 3-like 1 (CHI3L1) has recently been reported in hepatic and bowel inflammatory conditions. Considering that CHI3L1 plays a role as prognostic biomarker in multiple sclerosis (MS), here we investigated CHI3L1 as potential autoantigenic target in the disease. We determined serum CHI3L1 autoantibodies by enzyme-linked immunosorbent assay (ELISA) in a cohort of 60 untreated MS patients with different clinical forms of the disease and 20 healthy controls (HC). IgG levels to CHI3L1 were similar between patients with relapsing-remitting MS, primary and secondary progressive MS, and HC. These findings do not support a role for CHI3L1 autoantibodies in MS pathogenesis.

中文翻译：

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几丁质酶 3 样 1 不是多发性硬化患者的靶抗原

最近在肝脏和肠道炎症条件下报道了对几丁质酶 3 样 1 (CHI3L1) 的自身免疫。考虑到 CHI3L1 在多发性硬化症 (MS) 中作为预后生物标志物发挥作用，我们在此研究了 CHI3L1 作为该疾病中潜在的自身抗原靶点。我们通过酶联免疫吸附试验 (ELISA) 在一组 60 名患有不同临床疾病形式的未治疗 MS 患者和 20 名健康对照 (HC) 中测定了血清 CHI3L1 自身抗体。复发缓解型 MS、原发性和继发性进展型 MS 和 HC 患者对 CHI3L1 的 IgG 水平相似。这些发现不支持 CHI3L1 自身抗体在 MS 发病机制中的作用。