Frontiers in Chemistry ( IF 5.5 ) Pub Date : 2020-11-25 , DOI: 10.3389/fchem.2020.608296 Ola El Atab , Rabih Darwiche , Nathanyal J. Truax , Roger Schneiter , Kenneth G. Hull , Daniel Romo , Oluwatoyin A. Asojo
During their infective stages, hookworms release excretory-secretory (E-S) products, small molecules, and proteins to help evade and suppress the host's immune system. Small molecules found in E-S products of mammalian hookworms include nematode derived metabolites like ascarosides, which are composed of the sugar ascarylose linked to a fatty acid side chain. The most abundant proteins found in hookworm E-S products are members of the protein family known as
中文翻译:
美洲轮虫Anocylostoma分泌蛋白2(Na-ASP-2)在其脂肪酸结合位点结合了A虫苷(ascr#3)。
在感染阶段,钩虫释放出分泌分泌物(ES)产品,小分子和蛋白质,以帮助逃避和抑制宿主的免疫系统。在哺乳动物钩虫的ES产品中发现的小分子包括线虫衍生的代谢产物(例如a虫病),其由连接至脂肪酸侧链的糖Ascarylose组成。钩虫ES产品中发现的最丰富的蛋白质是该蛋白质家族的成员