The phytochemical investigation of Tarenna grandiflora led to the isolation of 18 known compounds of which were four flavones, three anthraquinones, one phenyl propanoic derivative, five triterpenoids, four steroids and a mixture of glucose. Luteolin ( 1 ) and soranjidiol ( 6 ) were allylated and/or prenylated to give four new semisynthesized derivatives which were fully characterized as 7,3′,4′- O -triallylluteolin ( 1a ), luteolin-7,3′,4′- O -triprenyls ( 1b ), luteolin-5,7,3′,4′- O -tetraprenyls ( 1c ) and 6- O -allylsoranjidiol ( 6a ). Their structures were established using spectroscopic analysis including 1D, 2D NMR and MS data. The cytotoxic, antioxidant and antimicrobial activities of extracts, fractions, isolated compounds and semi-synthesized derivatives were evaluated. The petroleum ether and EtOAc extracts exhibited good cytotoxic potency on KB-3-1 cell line with IC 50 of >0.1 and 0.025 mg/mL respectively, while compounds 1b and 11 were the most active (IC 50 > 0.0001 M). Compounds 1 and 3 showed the best antioxidant activities (45.5 and 55.8 µM); while compounds 9 and 12 showed the best antibacterial activities with MICs values ranges from 8.55 to 132 µM.

中文翻译：

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大花楝树的植物化学、抗菌、抗氧化和细胞毒性研究

Tarenna Grandiflora 的植物化学研究导致分离出 18 种已知化合物，其中包括四种黄酮、三种蒽醌、一种苯丙酸衍生物、五种三萜、四种类固醇和一种葡萄糖混合物。木犀草素 ( 1 ) 和 soranjidiol ( 6 ) 烯丙基化和/或异戊二烯化，得到四种新的半合成衍生物，这些衍生物完全表征为 7,3',4'-O-三烯丙基木犀草素 (1a), luteolin-7,3',4' - O-trirenyls (1b), luteolin-5,7,3',4'-O-tetraprenyls (1c) 和 6-O-allylsoranjidiol (6a)。它们的结构是使用光谱分析确定的，包括 1D、2D NMR 和 MS 数据。评估了提取物、馏分、分离的化合物和半合成衍生物的细胞毒性、抗氧化和抗微生物活性。石油醚和 EtOAc 提取物对 KB-3-1 细胞系显示出良好的细胞毒性，IC 50 分别为 >0.1 和 0.025 mg/mL，而化合物 1b 和 11 的活性最强（IC 50 > 0.0001 M）。化合物 1 和 3 显示出最好的抗氧化活性（45.5 和 55.8 µM）；而化合物 9 和 12 显示出最好的抗菌活性，MIC 值范围为 8.55 到 132 µM。