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Prevalence of ESBL-producing Escherichia coli and carbapenem-resistant Enterobacteriaceae in treated wastewater: a comparison with nosocomial infection surveillance
Journal of Water & Health ( IF 2.3 ) Pub Date : 2020-12-01 , DOI: 10.2166/wh.2020.014
Taro Urase 1 , Mitsuhiro Okazaki 2 , Hirofumi Tsutsui 3
Affiliation  

The increasing prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and carbapenem-resistant Enterobacteriaceae (CRE) is a worldwide health threat. Monitoring of these resistant bacteria in the environment can provide regional prevalence reflecting both healthy and infected populations, although the quantitative monitoring of those resistant bacteria, especially CRE, is difficult due to their low proportion in the total Enterobacteriaceae population and the possible interference by autochthonous species with intrinsic resistance. In this study, these resistant bacteria in treated wastewater were quantified at 12 different treatment plants. The proportions of cefotaxime-resistant and ESBL-producing E. coli in the total E. coli population in the chlorinated effluents in Tokyo were 5.7 and 5.3%, respectively. The estimated proportion of CRE was 0.007% with the constituting species of Klebsiella spp. and Enterobacter spp., although the conditions during the first incubation may have affected the estimation even after the correction by the proportion of resistant population in the isolates. The observed resistant proportions in this study were lower than those in the surveillance on nosocomial infection not only for inpatients but also for outpatients, and higher than those in the veterinary monitoring.



中文翻译:

处理废水中产ESBL的大肠杆菌和耐碳青霉烯的肠杆菌科细菌的患病率:与医院感染监测的比较

产生大范围β-内酰胺酶(ESBL)的大肠杆菌和耐碳青霉烯的肠杆菌科(CRE)的患病率日益增加,这对全世界的健康构成了威胁。监测环境中的这些抗性细菌可以提供反映健康人群和感染人群的区域流行情况,尽管由于这些抗性细菌(尤其是CRE)在肠杆菌科细菌总数中所占的比例较低以及可能受到本地种的干扰而很难对其进行定量监测具有内在的抵抗力。在这项研究中,在12个不同的处理厂对处理过的废水中的这些抗性细菌进行了定量。耐头孢噻肟和产ESBL的大肠杆菌在总大肠杆菌中所占的比例东京的氯化废水中的大肠杆菌数量分别为5.7%和5.3%。CRE的估计比例为克雷伯菌属种的0.007%。肠杆菌属和肠杆菌属,尽管即使在通过分离株中抗性种群的比例进行校正后,第一次孵育过程中的条件仍可能影响估计。在这项研究中观察到的耐药率不仅在住院病人中而且在门诊病人中均低于医院感染监测中的耐药率,也高于兽医监测中的耐药率。

更新日期:2020-12-17
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