Abstract

Cobalt ferrite (CoFe₂O₄) has numerous desirable features such as high anisotropy, good magnetic saturation, large coercivity and high mechanical strength. These remarkable characteristics provide extensive employment for their wide application from industrial to biomedical. The present study aims to evaluate the crystal properties, particle size, and morphology of CoFe₂O₄ nanoparticles prepared by the thermal treatment method and investigates their biocompatibility. XRD and FTIR analyses demonstrated that CoFe₂O₄ nanoparticles have an inverse cubic spinel crystalline structure. The average size of spherical CoFe₂O₄ nanoparticles was confirmed by SEM analysis as 58 nm. The cytotoxic effect of CoFe₂O₄ nanoparticles was evaluated in L929 cells by using the XTT cell viability assay. After 24 h treatment of CoFe₂O₄ nanoparticles with a concentration between 10 and 1000 µg/ml, the viability of L929 cells did not significantly decrease. It is concluded that growth CoFe₂O₄ nanoparticles are beneficial materials for use in various biomedical applications.

摘要

铁氧体钴（CoFe ₂ O ₄）具有许多期望的特征，例如高各向异性，良好的磁饱和度，大的矫顽力和高的机械强度。这些卓越的特性为其从工业到生物医学的广泛应用提供了广泛的就业机会。本研究旨在评估通过热处理方法制备的CoFe ₂ O ₄纳米颗粒的晶体性质，粒径和形态，并研究其生物相容性。XRD和FTIR分析表明，CoFe ₂ O ₄纳米颗粒具有倒立方尖晶石晶体结构。球形CoFe ₂ O ₄的平均尺寸通过SEM分析确认纳米颗粒为58nm。通过使用XTT细胞生存力测定法评估了Co929 ₂ O ₄纳米颗粒在L929细胞中的细胞毒性作用。在浓度为10至1000 µg / ml的CoFe ₂ O ₄纳米粒子处理24小时后，L929细胞的活力并未显着降低。结论是，生长CoFe ₂ O ₄纳米颗粒是用于各种生物医学应用的有益材料。