Abstract

Conducting polyaniline (PANI) brings together the electrical conductivity of metals with intriguing properties of plastics including facile processing as well as controllable chemical and physical properties. The nanoscaled PANI has attracted intense interest in various fields owing to the great physicochemical features including high conductivity, facile preparation, and fascinating redox behavior. PANI-based nanocomposites can help biocatalysts and bioreceptors including enzymes, antigen-antibodies, cells, and nucleic acids to immobilize on the surface in order to detect analytes and allow the biosensing process to occur at room temperature. In this article, an in-depth overview of the synthesis methods of PANI-based composites, their biomedical applications as biosensors, current states, challenges, and the potential application of them in the future have been presented and discussed. Additionally, recent PANI-based biosensing devices for the detection of glucose, cholesterol, choline, virus, cancer, and bacteria have been described.

摘要

导电聚苯胺（PANI）将金属的导电性与塑料的有趣特性（包括简便的加工以及可控的化学和物理特性）结合在一起。纳米级PANI由于其出色的理化特性（包括高电导率，易于制备和令人着迷的氧化还原行为）而在各个领域引起了浓厚的兴趣。基于PANI的纳米复合材料可以帮助生物催化剂和生物受体（包括酶，抗原抗体，细胞和核酸）固定在表面上，以检测分析物并允许在室温下发生生物传感过程。在本文中，将对基​​于PANI的复合材料的合成方法，其作为生物传感器的生物医学应用，当前状态，挑战，提出并讨论了它们在未来的潜在应用。另外，已经描述了用于检测葡萄糖，胆固醇，胆碱，病毒，癌症和细菌的最新的基于PANI的生物传感设备。