Abstract

An efficient eco-friendly procedure for the synthesis of spiro[indoline-3,11'-pyrazolo[3,4-a]acridine]-2,10'(1'H)-dione derivatives has been developed through a one-pot three-component condensation of 1H-indazol-6-amine, isatin, and 5,5-dimethyl cyclohexane-1,3-dione or cyclohexane-1,3-dione, in the presence of catalytic amount L-proline in EtOH at 60 °C conditions. The advantages of this protocol include mild reaction condition, green, and nontoxic solvent, high yield, and operational simplicity. IR, ¹H NMR, ¹³C NMR, HRMS spectras, and elemental analyses were used to identify the structures of all the synthesized compounds.

摘要

为螺环的合成的高效生态友好的过程[二氢吲哚3,11'吡唑并[3,4一]吖] -2,10-“（1” ħ） -二酮衍生物已经通过单罐开发1的三成分缩合ħ -吲唑-6-胺，靛红，和5,5-二甲基环己烷-1,3-二酮或环己烷-1,3-二酮，在催化量的存在大号脯氨酸在EtOH中在60°C条件。该方案的优点包括反应条件温和，绿色和无毒溶剂，高收率和操作简便。IR，¹ H NMR，¹³ C NMR，HRMS光谱和元素分析用于鉴定所有合成化合物的结构。