Abstract

A new cyclic peptide, Pseudostellarin K (1), together with thirteen known compounds, including two cyclic peptides (2 and 3), one β-carboline alkaloid (4), two amides (5 and 6), three phenylpropanoids (7–9) and other compounds (10–14), were isolated from the fibrous root of Pseudostellaria heterophylla. Their structures were elucidated by extensive spectroscopic analysis. Compounds 1, 4–6, 10 were isolated from the genus pseudostellaria for the first time. All compounds were evaluated for cytotoxic activities against MCF-7, A549, HCT-116 and SGC-7901 cell lines by MTT assay. Unfortunately, all these compounds displayed weak cytotoxic activities.

摘要

一种新的环状肽，伪硬脂酸K（1），以及十三种已知化合物，包括两个环状肽（2和3），一个β-咔啉生物碱（4），两个酰胺（5和6），三个苯基丙烷（7-9））和其他化合物（10-14）是从太子参的纤维根中分离出来的。通过广泛的光谱分析阐明了它们的结构。化合物1，4 - 6，10首次从假星菌属中分离出来。通过MTT分析评估所有化合物对MCF-7，A549，HCT-116和SGC-7901细胞系的细胞毒活性。不幸的是，所有这些化合物均显示出弱的细胞毒活性。