Abstract

This work obtained and identified pterocephanoside A (1), one new iridoid glucoside derivative with rare structure of three iridoid glycosides linked to cyclopenta[c]pyran-3(1H)-one, and 10 known iridoids (2–11) from Pterocephalus hookeri through silica gel column chromatography and semi-preparative HPLC. The structure of the new compound was confirmed by 1D and 2D NMR and HRMS data analysis. Compounds 1 and 2 were isolated from this plant for the first time. The iridoids mostly possessed seco-iridoid subtype and iridoid subtype skeletons from P. hookeri. Compounds 1, 3, 4, and 6–11 showed weak anti-inflammatory activity.

摘要

这项工作获得并鉴定了翼龙脑苷A（1），一种新的虹膜样糖苷衍生物，具有与环戊达[c] pyran-3（1H）-1相连的三个虹膜样糖苷的罕见结构，以及来自翼手蕨的10个已知虹膜样化合物（2-11）。通过硅胶柱色谱和半制备HPLC。通过1D和2D NMR和HRMS数据分析确认了新化合物的结构。化合物1和2首次从该植物中分离出来。虹膜类动物大多具有来自P. hookeri的seco-iridoid亚型和虹膜类亚型骨架。化合物1，3，4，和6 -11显示出较弱的抗炎活性。