Acetylcholine release is vital in the pacing of theta rhythms in the hippocampus. The subiculum is the output region of the hippocampus with different neuronal subtypes that generate theta oscillations during arousal and rapid eye movement sleep. The combination of intrinsic resonance in the hippocampal neurons and the periodic excitation of hippocampal excitatory and inhibitory neurons by cholinergic pathway drives theta oscillations. However, the acetylcholine mediated effect on intrinsic subthreshold resonance generating hyperpolarization‐activated cyclic nucleotide‐gated current, I_h of subicular neurons is unexplored. We studied the acetylcholine receptor‐independent effect of cholinergic agents on the intrinsic properties of subiculum principal neurons and the underlying mechanism.

中文翻译：

---

通过抑制超极化激活的环核苷酸门控通道对大鼠下叶神经元内在共振的独立胆碱能受体调节

乙酰胆碱的释放对于海马体中的 theta 节律的起搏至关重要。下丘是海马体的输出区域，具有不同的神经元亚型，在觉醒和快速眼动睡眠期间产生θ振荡。海马神经元的内在共振与胆碱能通路对海马兴奋性和抑制性神经元的周期性激发的结合驱动了θ振荡。然而，乙酰胆碱介导的内在亚阈值共振产生超极化激活的环核苷酸门控电流，亚突神经元的I _h尚未探索。我们研究了胆碱能药物对下叶主要神经元的内在特性和潜在机制的乙酰胆碱受体非依赖性影响。