The intranasal (IN) administration of radiopharmaceuticals is of interest in being a viable route for the delivery of radiopharmaceuticals that do not ordinarily cross the blood–brain barrier (BBB). However, to be viable in a patient population, good image quality as well as safety of the administration should be demonstrated. This work provides radiation dosimetry calculations and simulations related to the radiation safety of performing such experiments in a human cohort.

中文翻译：

---

使用蒙特卡洛模拟法估算因鼻腔施用PET药物而有风险的器官对皮肤的吸收辐射剂量和S值

鼻内（IN）给药放射性药物是一种可行的途径，可以输送通常不穿越血脑屏障（BBB）的放射性药物。但是，要在患者人群中可行，应证明良好的图像质量以及给药的安全性。这项工作提供了与在人类队列中进行此类实验的辐射安全性相关的辐射剂量学计算和模拟。